Weight-Loss Medications / Safety Information

Rx safety information

Important Safety Information for Tirzepatide

Tirzepatide is a prescription medication, and compounded versions are not FDA-approved and don't undergo the FDA's standard review for safety, effectiveness, or manufacturing. A licensed SD Clinic provider determines whether tirzepatide, and at what dose, is appropriate for you based on a full medical evaluation.

What tirzepatide is used for

Tirzepatide is used alongside diet and exercise to help improve blood sugar control in adults with type 2 diabetes. (Depending on your provider's evaluation, it may also be prescribed off-label for weight management.)

Warnings and precautions

• Thyroid C-cell tumors: cases of MTC have been reported in patients using GLP-1 receptor agonists, including tirzepatide. Your provider will assess your risk factors before starting treatment and monitor for signs of thyroid tumors.
• Pancreatitis: acute pancreatitis — including rare but serious hemorrhagic or necrotizing forms — has been reported with this class of medication. Stop tirzepatide and seek medical attention right away if you develop severe abdominal pain.
• Low blood sugar (hypoglycemia): risk increases when tirzepatide is combined with insulin or other medications that stimulate insulin release. Dose adjustments to those other medications may be needed.
• Kidney problems: acute kidney injury and worsening of existing kidney disease have been reported with GLP-1 receptor agonists, often related to dehydration from gastrointestinal side effects. Your provider will monitor kidney function, with added caution if you already have impaired kidney function.
• Serious allergic reactions: including anaphylaxis, swelling (angioedema), and hives. Stop tirzepatide immediately and seek medical care if this occurs.
• Gastrointestinal side effects: nausea, vomiting, diarrhea, and constipation are common and often ease over time or with a dose adjustment.

Most common side effects

The most frequently reported side effects (occurring in 5% or more of patients) are nausea, vomiting, diarrhea, abdominal pain, and constipation.

Pregnancy and breastfeeding

Tirzepatide should not be used during pregnancy, as it may cause harm to a developing baby. It isn't known whether tirzepatide passes into human breast milk, so caution is advised if you're breastfeeding — talk with your provider about the risks and alternatives.

Drug interactions

Tell your provider about all medications, supplements, and vitamins you're taking. Extra caution is needed with other drugs that affect digestion or gut absorption, and with any medication that increases the risk of low blood sugar.

What your provider will cover with you

Before starting tirzepatide, your provider should walk you through the potential benefits and risks, including gastrointestinal side effects and hypoglycemia risk, the importance of sticking with diet and exercise changes alongside treatment, and the warning signs of thyroid tumors, pancreatitis, and allergic reactions to watch for.